Chemical feeding port and chemical container with the port

ABSTRACT

A liquid-medicine injection port device includes: a liquid-medicine inlet which is formed at its upper end; a liquid-medicine outlet which is formed at its lower end which is connectable to a liquid-medicine container; a liquid passageway which connects the liquid-medicine inlet and the liquid-medicine outlet; a germ-removal filter which is provided in the liquid passageway; and a closure which closes the liquid passageway downstream from the germ-removal filter and opens it easily. Further, a liquid-medicine container is provided with this liquid-medicine injection port device. Or further, the liquid-medicine container has a two-chamber structure in which an injection chamber provided with the liquid-medicine injection port device which the germ-removal filter is attached to, and a storage chamber storing a liquid medicine, are divided by a weak seal portion having such a strength that it is easily peeled.

TECHNICAL FIELD

[0001] The present invention relates to a liquid-medicine injection portdevice, which is used for injecting and mixing liquid medicines,specifically mixing a liquid medicine into a liquid to be injected suchas a transfusion solution, aseptically and simply, and a liquid-medicinecontainer provided with the liquid-medicine injection port device.

BACKGROUND ART

[0002] Clinically, it is a matter of common practice that variousmedicines are simultaneously given to a patient. For example, in thecase of injecting vitamins or the like into a vein, they must not bestored in a liquid-medicine container such as a transfusion-solutionpack and conduct high-pressure steam sterilization processingbeforehand. This is because vitamins deteriorate upon heated. When usingit, therefore, it is necessary to inject and mix (referred to asinjection-mix) it into a liquid-medicine container which stores anotherliquid medicine in advance. In short, mixing needs to be conducted inthe liquid-medicine container.

[0003] If the above described liquid medicine is injection-mixed into aliquid-medicine container, conventionally, there has been used theinjection-mixing method of piercing a rubber stopper of aliquid-medicine discharge port in the liquid-medicine container with aninjection needle. In this method, however, it has been hard to ensureasepsis when an injection-mixing operation is conducted. Ifmicroorganisms (or germs) get mixed from the outside when theinjection-mixing operation is conducted, the microorganisms propagatethemselves in a mixed injection solution while the mixed injectionsolution is given to a patient. Especially, if an injection solution is,for example, a transfusion solution for nutrition, such as ahigh-calorie transfusion solution, there is a risk that microorganismsmay propagate themselves while it is given, even though only a smallnumber of microorganisms get mixed inside. Thus, there is a possibilitythat numerous microorganisms may be injected, together with thetransfusion solution, into the body of a patient during the latter partof the time when the transfusion solution is given. If such a mixedinjection solution is given, that produces some serious side effectssuch as septicemia and endotoxin shock on the patient. Hence, it isnecessary to take the safety of a patient sufficiently into account, sothat asepsis can be secured when an injection-mixing operation isconducted.

[0004] It is an object of the present invention to provide aliquid-medicine injection port device which is capable of injecting aliquid medicine aseptically and has a smaller number of component partsand a smaller and simpler structure than in any conventional ones, and aliquid-medicine container provided with this liquid-medicine injectionport device.

DISCLOSURE OF THE INVENTION

[0005] A liquid-medicine injection port device according to the presentinvention, as the gist thereof, comprising: a liquid-medicine inletwhich is formed at an upper end thereof; a liquid-medicine outlet whichis formed at a lower end thereof, the liquid-medicine outlet beingconnected to a liquid-medicine container; a liquid passageway whichconnects the liquid-medicine inlet and the liquid-medicine outlet; agerm-removal filter which is provided in the liquid passageway; and aclosure which closes the liquid passageway underneath the germ-removalfilter and opens the liquid passageway easily.

[0006] Furthermore, in this liquid-medicine injection port device, theclosure may be used which is opened by the injection pressure of aliquid medicine which is injected from the liquid-medicine inlet.

[0007] Furthermore, this closure may be a film which blocks the liquidpassageway. The film has a weak part which is broken by aliquid-medicine injection pressure.

[0008] Furthermore, this closure may be a film which blocks theliquid-medicine outlet. The film is melted and attached, or is glued, tothe periphery of the liquid-medicine outlet to cover the liquid-medicineoutlet; and the strength of the melting-attachment or gluing is such adegree that the film is peeled by a liquid-medicine injection pressure.

[0009] Furthermore, this closure may be a cylindrical film which blocksthe liquid-medicine outlet. One end of the film is fixed with kept openon the periphery of the liquid-medicine outlet to cover theliquid-medicine outlet; and the interior surfaces of the other endthereof are melted and attached, or are glued, to each other to closethe other end, at such a strength that it is broken by a liquid-medicineinjection pressure.

[0010] Furthermore, this closure may be an elastic member which blocksthe liquid-medicine outlet. The elastic member is deformed by receivinga liquid-medicine injection pressure to open the liquid-medicine outlet.

[0011] Furthermore, this closure may be a closure member which isinserted into the liquid-medicine outlet. The closure member clings tothe inside of the liquid-medicine outlet, at such a strength that itcomes off the liquid-medicine outlet by a liquid-medicine injectionpressure.

[0012] Furthermore, in this closure, a means may be provided whichreceives the closure member that comes off the liquid-medicine outletwhen a liquid medicine is injected.

[0013] Furthermore, in a liquid-medicine injection port device providedwith such a closure, the liquid-medicine inlet is sealed up with arubber elastic body which-is pierced with an injection needle to form aliquid-medicine storage space between the liquid-medicine inlet and thegerm-removal filter; a compressor may be provided which compresses theinner volume of the liquid-medicine storage space; and theliquid-medicine injection pressure of a liquid medicine which is onceinjected into the liquid-medicine storage space is heightened by thecompressor to compressively send the liquid medicine to the side of thegerm-removal filter.

[0014] Furthermore, particularly, in this liquid-medicine injection portdevice, the closure may be used which is opened by a movement of amain-body member provided with the liquid-medicine inlet and thegerm-removal filter.

[0015] Furthermore, in this closure, an up-and-down movement of themain-body member may allow the closure member to be moved or broken toopen the closure.

[0016] Furthermore, in this closure, the main-body member may be slid upand down. The liquid-medicine outlet which is formed in a side of ahanging portion of the main-body member is blocked with a slide surfacewhen the main-body member is in an upper position; and it is away fromthe slide surface and opened when it is slid downward.

[0017] Furthermore, in this closure, a turning operation of themain-body member may allow the closure member to be moved or broken toopen the closure.

[0018] Furthermore, in this closure, the main-body member may be madeturnable. The liquid-medicine outlet is formed in the side of a hangingportion of the main-body member; and an opening portion which leads tothe outside is provided at a part of a turning-and-rubbing surface withwhich the liquid-medicine outlet is in contact.

[0019] Furthermore, in this closure, underneath the main-body member, aninner-lid member may be provided which engages with the main-body memberso as to turn together with the main-bodymember. The inner-lidmember ishoused in the liquid passageway which is relatively widened; at leasttwo liquid-medicine outlets are provided which are in contact with thelower surface of the inner-lid member and are away from theturning-center axis of the main-body member; and the inner-lid memberhas blind parts which cover the liquid-medicine outlets from the insideand has such a shape that the liquid-medicine outlets are opened byturning of the inner-lid member.

[0020] Furthermore, particularly, in this liquid-medicine injection portdevice, the closure may be an open-and-close valve which blocks theliquid passageway. The open-and-close valve is opened by an operation ofan operation member, which penetrates the side wall of theliquid-medicine injection port device and is connected to theopen-and-close valve.

[0021] Furthermore, in this closure, the open-and-close valve may beopened by turning the operation member.

[0022] Furthermore, in this closure, the open-and-close valve may beopened with a slide of the operation member, the slide crossing theliquid passageway.

[0023] Furthermore, particularly, in this liquid-medicine injection portdevice, the closure may be a partition wall which blocks theliquid-medicine outlet. The partition wall is broken and opened by anoperation of an operation member which penetrates the side wall of theliquid-medicine injection port device.

[0024] Furthermore, a liquid-medicine container provided with theliquid-medicine injection port device according to the presentinvention, as the gist thereof, comprising a liquid-medicine injectionport device according to any of the above described ones.

[0025] Furthermore, a liquid-medicine container provided with theliquid-medicine injection port device according to the presentinvention, as another gist thereof, which includes a liquid-medicineinjection port device and a liquid-medicine discharge port device, isprovided with two front and back sheets and is shaped like a bag, inwhich: an injection chamber provided with a liquid-medicine injectionport device and a storage chamber storing a liquid medicine in advanceare divided by a weak seal portion which is formed by melting andattaching, or gluing, the two front and back sheets to each other atsuch a strength that they are easily peeled.

[0026] Furthermore, particularly, this weak seal portion may be peeledby receiving the injection pressure of a liquid medicine which isinjected from the liquid-medicine injection port device to allow theinjection chamber to lead to the storage chamber.

[0027] Particularly, a projection may be formed in either or both of thefront and back surfaces of this weak seal portion. The projection ispicked up and pulled so that the weak seal portion is peeled andseparated into the two front and back sheets.

BRIEF DESCRIPTION OF THE DRAWINGS

[0028]FIG. 1 is a longitudinal sectional view of a liquid-medicineinjection port device according to the present invention.

[0029]FIG. 2 is a front view of a liquid-medicine container according tothe present invention.

[0030]FIG. 3 shows details of an outlet member shown in FIG. 1,according to the present invention; FIG. 3A being a top view; FIG. 3Bbeing a longitudinal sectional view; and FIG. 3C being a bottom view.

[0031]FIG. 4 illustrates the shape of a weak part which is formed in aclosure film shown in FIG. 1, according to the present invention; FIG.4A showing the shape of a cross; FIG. 4B showing the shape of a circle;and FIG. 4C showing the shape of a tongue.

[0032]FIG. 5 shows another liquid-medicine injection port deviceaccording to the present invention; FIG. 5A being a longitudinalsectional view; and FIG. 5B being a front view of a liquid-medicineoutlet and its vicinity.

[0033]FIG. 6 is a longitudinal sectional view of the liquid-medicineoutlet and its vicinity according to the present invention.

[0034]FIG. 7 is a longitudinal sectional view of another liquid-medicineinjection port device according to the present invention.

[0035]FIG. 8 shows still another liquid-medicine injection port deviceaccording to the present invention; FIG. 8A being a longitudinalsectional view; and FIG. 8B being a front view of a liquid-medicineoutlet and its vicinity.

[0036]FIG. 9 shows the liquid-medicine outlet and its vicinity accordingto the present invention; FIG. 9A being a longitudinal sectional view;and FIG. 9B being a front view.

[0037]FIG. 10 is a longitudinal sectional view of still anotherliquid-medicine injection port device according to the presentinvention.

[0038]FIG. 11 shows still another liquid-medicine injection port deviceaccording to the present invention; FIG. 11A being a longitudinalsectional view of the whole injection port device; and FIG. 11B being abottom view of a capture member and its vicinity.

[0039]FIG. 12 is a longitudinal sectional view of still anotherliquid-medicine injection port device according to the presentinvention.

[0040]FIG. 13 is a longitudinal sectional view of still anotherliquid-medicine injection port device according to the presentinvention.

[0041]FIG. 14 is a longitudinal sectional view of still anotherliquid-medicine injection port device according to the presentinvention.

[0042]FIG. 15 is a longitudinal sectional view of still anotherliquid-medicine injection port device according to the presentinvention.

[0043]FIG. 16 is a longitudinal sectional view of still anotherliquid-medicine injection port device according to the presentinvention.

[0044]FIG. 17 is a top view of an outlet member of the liquid-medicineinjection port device shown in FIG. 16, according to the presentinvention.

[0045]FIG. 18 is a longitudinal sectional view of still anotherliquid-medicine injection port device according to the presentinvention.

[0046]FIG. 19 shows still another liquid-medicine injection port deviceaccording to the present invention; FIG. 19A being a longitudinalsectional view of the whole injection port device; FIGS. 19B and 19Cbeing sectional views, seen along the line 19-19 in FIG. 19A; FIG. 19Bshowing a state in which a liquid-medicine outlet is closed; and FIG.19C showing a state in which the liquid-medicine outlet is opened.

[0047]FIG. 20 is a longitudinal sectional view of still anotherliquid-medicine injection port device according to the presentinvention.

[0048]FIG. 21 is a sectional view, seen along the line 21-21 in FIG. 20,according to the present invention; FIG. 21A showing a state in which aliquid-medicine outlet is closed, and FIG. 21B showing a state in whichthe liquid-medicine outlet is opened.

[0049]FIG. 22 is a longitudinal sectional view of still anotherliquid-medicine injection port device according to the presentinvention.

[0050]FIG. 23 is a top view of an operation member in FIG. 22, accordingto the present invention.

[0051]FIG. 24 is a perspective view of another operation member in FIG.22, according to the present invention.

[0052]FIG. 25 is a longitudinal sectional view of still anotherliquid-medicine injection port device according to the presentinvention.

[0053]FIG. 26 is a top view of an operation member in FIG. 25, accordingto the present invention.

[0054]FIG. 27 is a longitudinal sectional view of still anotherliquid-medicine injection port device according to the presentinvention.

[0055]FIG. 28 is a front view of another liquid-medicine containeraccording to the present invention.

[0056]FIG. 29 is a front view of still another liquid-medicine containeraccording to the present invention.

[0057]FIG. 30 is a sectional view of a weak seal portion according tothe present invention.

[0058]FIG. 31 is a sectional view of another weak seal portion accordingto the present invention.

BEST MODE FOR CARRYING OUT THE INVENTION

[0059] Next, embodiments of a liquid-medicine injection port device anda liquid-medicine container according to the present invention will bedescribed in detail with reference to drawings.

[0060]FIG. 1 shows a preferred liquid-medicine injection port device 10embodying the present invention. FIG. 2 shows a liquid-medicinecontainer (or a transfusion-solution pack) 12 which the liquid-medicineinjection port device 10 is attached to. The liquid-medicine injectionport device 10 is configured by: a main-body member 20 which is formedby placing an inlet member 14, a germ-removal filter 16 and an outletmember 18 on top of one another in that order; a cylindrical member 22which the side part of the main-body member 20 is held in; a cap 26which covers a liquid-medicine inlet 24 formed in the upper end of theinlet member 14 and is attachable thereto, and detachable therefrom; anda closure film 30 which blocks a liquid-medicine outlet 28 formed in thecentral lower part of the outlet member 18. A flange 32 formed at thelower end of the cylindrical member 22 is melted and attached to aflange 34 formed at the upper end of the liquid-medicine container 12,so that the liquid-medicine injection port device 10 is fixed on theupper part of the liquid-medicine container 12. A liquid passageway 36is formed which leads from the liquid-medicine inlet 24, through theinlet member 14, the germ-removal filter 16 and the outlet member 18, tothe liquid-medicine outlet 28.

[0061] In the liquid-medicine injection port device 10 according to thepresent invention, the upside means the side on which theliquid-medicine inlet 24 is provided, and the downside means the side onwhich the liquid-medicine outlet 28 is provided in the direction whereit is connected to the liquid-medicine container 12. The liquid-medicineinlet 24 is shaped so as to be connected to a syringe which stores aliquid medicine to be injection-mixed, and it is gently tapered offdownward. The germ-removal filter 16 is disposed with its front surfacewide open, so that a liquid medicine can be filtrated over an area aslarge as possible. As shown in FIG. 3, in the upper surface of theoutlet member 18 are formed circular grooves 38 and radial grooves 40 ingreat numbers. This allows the liquid medicine which has passed throughthe germ-removal filter 16 to flow toward the liquid-medicine outlet 28formed in its central part and to converge in it.

[0062] In the lower surface of the outlet member 18, there are formedtwelve projections 42 which doubly surround the liquid-medicine outlet28, and in addition, a circular projection 44 which surrounds them. Theclosure film 30 is melted and attached to the circular projection 44 toblock the liquid-medicine outlet 28. The twelve projections 42 have thefunction of supporting the closure film 30 against the pressure appliedon the closure film 30 from behind. The projections 42 are suitably awayfrom each other, so that a liquid medicine can move freely between theseprojections 42.

[0063] In the closure film 30 is formed a weak part which is broken by aliquid-medicine injection pressure. The weak part is formed withscratches engraved by a Thomson blade, a heat press or the like,perforations, or the like. For example, a weak part 46 shown in FIG. 4Ais a cross-engraved scratch. It usually closes the liquid-medicineoutlet 28, and does not break even though coming into contact with aliquid medicine in the liquid-medicine container 12. This prevents itfrom going into the liquid-medicine injection port device 10. Ifinjection-mixing is conducted from the liquid-medicine inlet 24, theweak part 46 receives the injection pressure of the injection-mixedliquid medicine through the liquid-medicine outlet 28. Then, this thinscratch is broken and opened downward, and thus, the closed liquidpassageway 36 is opened and leads to the inside of the liquid-medicinecontainer 12.

[0064] In the closure film 30 shown in FIG. 4B is formed the weak part46 which is a circular scratch. If it receives a liquid-medicineinjection pressure, then its circular hole is designed to open. In theclosure film 30 shown in FIG. 4C is formed the U-shaped weak part 46,and its opening part would be formed which hangs down like a tongue.However, the shape of the weak part 46 is not limited to theseillustrations. It is most suitably designed according to the propertyand state of an injection-mixed liquid medicine, injection-mixingpressure, or the like.

[0065] With respect to the liquid-medicine injection port device 10according to the present invention which has such a structure asdescribed above, as shown in FIG. 2, when it is attached to theliquid-medicine container 12, a liquid medicine is injected from theliquid-medicine inlet 24 before the closure film 30 is broken. Thus, theliquid passageway 36 leads to the liquid-medicine container 12. Thisprevents the liquid medicine. stored in the liquid-medicine container 12from going into the liquid-medicine injection port device 10, at leastbefore it is used (or before an injection-mixing operation isconducted). In addition, with the liquid-medicine injection port device10 kept attached, the liquid medicine stored in the liquid-medicinecontainer 12 is aseptically held. Besides, injection-mixing can beeasily conducted without doing any other special work. All you have todo is to take off the cap 26 and inject a liquid medicine from theliquid-medicine inlet 24.

[0066] As the germ-removal filter 16, especially, limitations are notnecessarily placed, but each type of filter usually used in the art maybe suitably used, for example, a membrane type, a screen type, a depthtype, an anisotropic type, or the like. Among them, the membrane-typefilter is especially preferable. If the germ-removal filter 16 isrealized with the membrane-type, its hole diameter (or mesh fineness)should preferably be chosen to be 0.01 μm to 1.0 μm, so that it can cutoff the passage of germs. More preferably, it should be chosen 0.01 μmto 0.5 μm. In addition, as a material forming the germ-removal filter16, there are enumerated cellulose acetate, regenerated cellulose,cellulose ester, nylon, polytetrafluoroethylene, polystyrene,polycarbonate, acrylic-system resin, polyolefin, polyvinylidenedifluoride, polyether sulfone, and the like. However, it is not limitedto these.

[0067] The material of the inlet member 14, the outlet member 18, thecylindrical member 22, the cap 26 and the like, is not limitedespecially. However, plastics having superior moldability are usedpreferably. Above all, it is especially preferable that materials havinggreat chemical-resistance to a liquid medicine to be injection-mixed,great heat-resistance to high-pressure steam sterilization, superiormelting-and-attaching properties useful for the connection between eachmember or their connection to the liquid-medicine container 12, and thelike, are used, such as polyethylene, polypropylene, polyvinyl chloride,polyester, polycarbonate, and the like. Preferably, the outlet member 18should be the same material as the liquid-medicine container 12, so thatthey can be easily connected by melting attachment.

[0068] In addition, the closure film 30 is not especially limited, aslong as it has chemical-resistance and a suitable thickness for formingthe weak part 46. Preferably, it should be melted and attached to thecircular projection 44. To do this, it is preferable that a film is usedwhich is made of the same material as the outlet member 18, or amaterial blended with the material of the outlet member 18. For example,if the outlet member 18 is made of polyethylene, then polyethylene, apolymer blend of polyethylene and polypropylene, or the like, is usedpreferably. However, a film which is difficult to melt and attach to theoutlet member 18 may also be used and glued to the circular projection44 to close the liquid-medicine outlet 28.

[0069] The liquid-medicine container 12 provided with theliquid-medicine injection port device 10 according to the presentinvention is sterilized in advance before it is used (orinjection-mixing is conducted). Specifically, with storing a liquidmedicine in the liquid-medicine container 12, it undergoes processing,such as high-pressure steam sterilization, ethylene-oxide gassterilization, and γ-ray sterilization. Then, it is sealed with the cap26 to be kept aseptic. When injection-mixing is conducted, first, thecap 26 is removed, and then, using a syringe or an injection needle, aliquid medicine is injected from the liquid-medicine inlet 24. The germswhich have got mixed into the injected liquid medicine are hindered frompassing through the germ-removal filter 16, and thus, stop short of theinside of the liquid-medicine container 12. Therefore, theinjection-mixed injection solution remains aseptic, allowing it to besafely given to a patient.

[0070] A closure in the liquid-medicine injection port device 10 shownin FIG. 5 is the closure film 30 blocking the liquid-medicine outlet 28.The liquid-medicine injection port device 10 is configured by: themain-body member 20 which is a so-called top-shaped filter including theliquid-medicine inlet 24 and the germ-removal filter 16; the cylindricalmember 22 connected to the lower part of the main-body member 20; andthe cap 26 covering the liquid-medicine inlet 24. The cylindrical member22 is inserted into the liquid-medicine container 12. Then, it is meltedand attached, or glued, to an edge portion 13 of the liquid-medicinecontainer 12 (omitted in the figure). Thereby, it is fixed airtightthereto.

[0071] In this liquid-medicine injection port device 10, theliquid-medicine outlet 28 is formed in the lowermost side wall of thecylindrical member 22 and is blocked with the closure film 30. Theclosure film 30 is melted and attached, or glued, to the periphery ofthe liquid-medicine outlet 28. The strength of the melting-attachment orgluing is such a degree that it is peeled by a liquid-medicine injectionpressure applied when a liquid medicine has been injected from theliquid-medicine inlet 24. Thus, before it is used, the liquid-medicineoutlet 28 is blocked with the closure film 30, thereby preventing aliquid medicine in the liquid-medicine container 12 from going into theliquid-medicine injection port device 10. If injection-mixing isconducted, the closure film 30 is peeled to open the liquid-medicineoutlet 28 automatically. Then, the injected liquid medicine goes intothe liquid-medicine container 12 and is mixed with a liquid medicinealready stored in the liquid-medicine container 12.

[0072] According to this embodiment in which the liquid-medicine outlet28 is blocked with the film at such a strength that it is peeled by aliquid-medicine injection pressure, the location or shape of theliquid-medicine outlet 28 is not limited especially. FIG. 6 shows anexample in which the liquid-medicine outlet 28 is formed in the bottomof the cylindrical member 22. Alternatively, using a configurationsimilar to that shown in FIG. 1, the strength at which the closure film30 is fixed on the outlet member 18 may also be suitably controlled sothat it can be easily peeled. Preferably, a part of the peeled closurefilm 30 should remain attached so that it will not fall into theliquid-medicine container 12.

[0073] The liquid-medicine injection port device 10 shown in FIG. 7shows another preferred embodiment according to the present invention.As the closure of blocking the liquid passageway 36 is used acylindrical film, and one of its ends is closed. Specifically, an openedend 48 of a cylindrical film 52 is fixed on the periphery of theliquid-medicine outlet 28 to cover the liquid-medicine outlet 28. Theinterior surfaces of its other end 50 are melted and attached to eachother to close it, at such a strength that it is broken by aliquid-medicine injection pressure. Therefore, when a liquid medicinehas been injected from the liquid-medicine inlet 24, the closed end 50of the cylindrical film 52 is opened by the liquid-medicine injectionpressure. Thus, the injected liquid medicine goes into theliquid-medicine container 12 (refer to FIG. 2). The means of fixing theopened end 48 of the cylindrical film 52 on the periphery of theliquid-medicine outlet 28 is not limited, but melting attachment,gluing, banding or the like, is preferable. The interior surfaces of theother end 50 may be melted and attached to each other. However, theirmelting attachment may also be conducted by placing a different kind offilm between them. Herein, the film which blocks the liquid passageway36 may also be disposed in the liquid passageway 36.

[0074]FIG. 8 shows an example in which the closure is an elastic memberwhich blocks the liquid-medicine outlet 28. The liquid-medicine outlet28 formed in the lowermost side of the cylindrical member 22 is coveredwith a tube 29 which is a rubber elastic body. This prevents a liquidmedicine in the liquid-medicine container 12 from going into theliquid-medicine injection port device 10. When a liquid medicine forinjection-mixing is injected from the liquid-medicine inlet 24, the tube29 is swelled by the injection pressure. This creates a gap between itand the cylindrical member 22 and opens the liquid-medicine outlet 28.After the injection has stopped, the tube 29 returns to its initialposition again and blocks the liquid-medicine outlet 28. In other words,the tube 29 functions as a check valve.

[0075] In another example shown in FIG. 9, a plate spring 37 is used asthe elastic member which blocks the liquid-medicine outlet 28. The platespring 37 is warped by receiving a liquid-medicine injection pressure.This creates a gap between it and the cylindrical member 22 and opensthe liquid-medicine outlet 28.

[0076] The liquid-medicine injection port device 10 shown in FIG. 10 issimilar to the liquid-medicine injection port device 10 shown in FIG. 1,but the closure film 30 which blocks the liquid-medicine outlet 28 isreplaced with the plate spring 37 used as the elastic member. However,the elastic member is not limited to the above described illustration. Acoiled spring or the like may also be used.

[0077] In the liquid-medicine injection port device 10 shown in FIG. 11,as the means of blocking the liquid passageway 36 is used a closuremember 58 which is inserted into the liquid-medicine outlet 28.Specifically, the liquid-medicine outlet 28 is blocked by inserting thesubstantially-spherical closure member 58 into the liquid-medicineoutlet 28 having a circular cross section. The closure member 58 clingsto the inside of the liquid-medicine outlet 28, at such a strength thatit comes off the liquid-medicine outlet 28 by a liquid-medicineinjection pressure. Therefore, when a liquid medicine has been injectedfrom the liquid-medicine inlet 24, the closure member 58 comes off andis released from the liquid-medicine outlet 28 by the liquid-medicineinjection pressure. Thus, the liquid passageway 36 is opened. The shapeof the closure member 58 is suitably selected in line with the shape ofthe liquid-medicine outlet 28. Specifically, for the circularcross-section liquid-medicine outlet 28, it should suitably bespherical, cylindrical, bottomed conical, or the like. Besides, it ispreferable that the liquid-medicine outlet 28 has a proper degree ofelasticity.

[0078] In this example, a receiving member 54 is attached to the bottomof the liquid-medicine outlet 28. It receives the closure member 58which comes off and is released by the liquid-medicine injectionpressure, thereby preventing it from falling into the liquid-medicinecontainer 12 (refer to FIG. 2). This is aimed at evading occurrence ofsome trouble, such as the blockage of the inlet of a liquid-medicinedischarge port device 60 (refer to FIG. 2) in the liquid-medicinecontainer 12 with the fallen closure member 58. In the receiving member54, an opening portion 56 is formed which has asubstantially-rectangular shape that is narrower than the closure member58. This allows a liquid medicine to pass through both its sides, eventhough it receives the closure member 58.

[0079] In the liquid-medicine injection port device 10 shown in FIG. 12,a compressor is provided which heightens a liquid-medicine injectionpressure secondarily. A slide member 66 is disposed which can slidealong the upper cylindrical interior-surface of the inlet member 14. Theliquid-medicine inlet 24 formed in this slide member 66 is sealed upwith a stopper body 62 which is formed with a rubber elastic body andthat can be pierced with an injection needle. Between the stopper body62 and the germ-removal filter 16 is formed a liquid-medicine storagespace 64. When injection-mixing is conducted, using the injection needlewhich pierces the stopper body 62, a liquid medicine is first injectedinto the liquid-medicine storage space 64. Next, the liquid-medicinestorage space 64 is compressed by moving down the slide member 66. Sincethe side of the liquid-medicine inlet 24 is sealed up, the liquidmedicine once stored in the liquid-medicine storage space 64 receivesthe compression pressure strongly and flows onto the side of thegerm-removal filter 16. Then, the strong compression pressure istransmitted to a closure provided underneath the germ-removal filter 16to open the closure. The closure in this example is the closure film 30which blocks the liquid-medicine outlet 28. The closure film 30 which ismelted and attached to the circular projection 44 of the outlet member18 receives the liquid-medicine injection pressure and is peeled.Herein, an interlock mechanism may also be provided which prevents theslide member 66 from moving down before the liquid-medicine injectionport device 10 is used.

[0080] If it is used in the liquid-medicine injection port device 10provided with a closure which is opened by a liquid-medicine injectionpressure, this contrivance for heightening the liquid-medicine injectionpressure secondarily helps open the closure more certainly. This isespecially effective in the case where a liquid medicine is injectedusing an injection needle under relatively-low injection pressure. Asthe closure used together, any one may be used, as long as it is openedby a liquid-medicine injection pressure. It includes the closure alreadydescribed using FIG. 1 to FIG. 11 or the like, in short, it is notespecially limited.

[0081]FIG. 13 and FIG. 14 show examples in which the main-body member 20including the liquid-medicine inlet 24 and the germ-removal filter 16moves up and down, thereby moving or breaking a closure to open theclosure. Specifically, the liquid-medicine injection port device 10shown in FIG. 13 is an example which has the function of breaking theclosure. The main-body member 20 and a slide member 23 can move up anddown together in the cylindrical member 22. In the slide member 23, theliquid-medicine outlet 28 is formed near its pointed end, as if it werea rocket needle. An opening portion 39 formed at the bottom of thecylindrical member 22 is blocked with the closure film 30. Therefore, ifthe cap 26 covering the main-body member 20 is pushed down, the slidemember 23 moves down together with the main-body member 20. Then, itspointed end breaks through the closure film 30, allowing the liquidpassageway 36 to lead to the liquid-medicine container 12.

[0082] The liquid-medicine injection port device 10 shown in FIG. 14 hasthe function of moving the closure. In this liquid-medicine injectionport device 10, in the same way as the liquid-medicine injection portdevice 10 shown in FIG. 11, the liquid-medicine outlet 28 is blocked byinserting the substantially-spherical closure member 58 into theliquid-medicine outlet 28 having a circular cross section. Since theliquid-medicine outlet 28 is formed at the bottom of the cylindricalmember 22, if the cap 26 is pushed down and the slide member 23 is moveddown to get her with the main-body member 20, then the lower end of theslide member 23 hits on the closure member 58. Thus, it is pushed out ofthe liquid-medicine outlet 28, allowing the liquid passageway 36 to leadto the liquid-medicine container 12.

[0083] In the liquid-medicine injection port device 10 shown in FIG. 15,the main-body member 20 formed by the inlet member 14, the germ-removalfilter 16 and the outlet member 18 can slide up and down along theinterior surface of the cylindrical member 22. The liquid-medicineoutlet 28 formed in the side of a hanging portion 68 of the outletmember 18 is blocked with a slide surface 74 when the main-body member20 is in an upper position. On the other hand, it is away from the slidesurface 74 and is opened when it has been slid downward. Before it isused (or injection-mixing is conducted), the liquid-medicine outlet 28is kept closed. This prevents the liquid medicine stored in theliquid-medicine container 12 (refer to FIG. 2) from going into theliquid-medicine injection port device 10. Injection-mixing is conductedby moving down the main-body member 20, removing the cap 26 andinjecting the liquid medicine from the liquid-medicine inlet 24. Herein,an interlock mechanism may also be provided which prevents the main-bodymember 20 from moving down before it is used.

[0084] The liquid-medicine injection port device 10 shown in each ofFIG. 16, FIG. 18, FIG. 19 and FIG. 20 has the function of opening theclosure by turning the main-body member 20. In the liquid-medicineinjection port device 10 shown in FIG. 16, the main-body member 20 andthe cylindrical member 22 can turn together around an outlet member 25to be connected to the liquid-medicine container 12 (omitted in thefigure). In the outlet member 25, a large number of holes 28 are formedas a liquid-medicine outlet, and are covered and blocked from above withthe horseshoe closure film 30 (refer to FIG. 17). A ring 31 formed at anend of the closure film 30 is hooked on a claw 33 for hanging. The claw33 is formed at the bottom of the main-body member 20 and extends fromits center to periphery. Hence, if the main-body member 20 and thecylindrical member 22 are turned in the direction of an arrow, the claw33 turns with hooking the ring 31. Thus, the closure film 30 isgradually wound from the side of the ring 31 to open the liquid-medicineoutlet 28.

[0085] In the liquid-medicine injection port device 10 shown in FIG. 18,the liquid-medicine outlet 28 is blocked with the inclined closure film30. At the bottom of the main-body member 20, a pin 35 is disposeddownward on the side where the film 30 is farther away from it. Thus, ifthe main-body member 20 is turned, the pin 35 hits on the closure film30 and breaks it to open the liquid-medicine outlet 28.

[0086] In the liquid-medicine injection port device 10 shown in FIG. 19,the main-body member 20 formed by the inlet member 14, the germ-removalfilter 16 and the outlet member 18 can turn along the interior surfaceof the cylindrical member 22. The liquid-medicine outlet 28 is formed inthe side of the hanging portion 68 of the outlet member 18. Theliquid-medicine outlet 28 turns with keeping in contact with a rubbingsurface 76. In a part of the rubbing surface 76 is provided an openingportion 78 which leads to the outside. Hence, before it is used, aturning position of the liquid-medicine outlet 28 is determined so thatit is covered with the rubbing surface 76 (refer to FIG. 19B). When itis used, the main-body member 20 is turned so that the liquid-medicineoutlet 28 and the opening portion 78 can meet (refer to FIG. 19C).Before it is used, the liquid-medicine outlet 28 is closed, therebypreventing the liquid medicine stored in the liquid-medicine container12 (refer to FIG. 2) from going into the liquid-medicine injection portdevice 10. Injection-mixing is conducted by turning the main-body member20, removing the cap 26 and injecting the liquid medicine from theliquid-medicine inlet 24 with a syringe or the like.

[0087] In the liquid-medicine injection port device 10 shown in FIG. 20,a cup-shaped bottom member 80 is provided underneath the outlet member18. It and the outlet member 18 form the broad and relatively-spaciousliquid passageway 36. In this liquid passageway 36, an inner-lid member82 is provided which engages with the main-body member 20 so as to turntogether with the main-body member 20. In the bottom member 80, twoliquid-medicine outlets 28 are formed which are in contact with thelower surface of the inner-lid member 82 and that are away from aturning-center axis 92 of the main-body member 20.

[0088] As shown in FIG. 21, the inner-lid member 82 has a flat-plateportion 94 which is shaped like substantially a pair of dumbbells, andtwo pole-shaped pillars 96 which is erected from it. The flat-plateportion 94 has two substantially-circular blind parts 88 on both itssides and has an arrow part 90 in the middle. Before the liquid-medicineinjection port device 10 is used, the liquid-medicine outlets 28 formedin the bottom member 80 are covered with the blind parts 88. When it isused, however, the inner-lid member 82 is turned by an angle of 90degrees to move the blind parts 88, thereby opening the liquid-medicineoutlets 28. The two pole-shaped pillars 96 of the inner-lid member 82are inserted into two holes 98 formed in the outlet member 18 to engagewith them. Thus, they are turned along with the main-body member 20united with the cylindrical member 22, as it is turned.

[0089] In this embodiment, the lower surfaces of the blind parts 88 ofthe inner-lid member 82 which cover the liquid-medicine outlets 28 mayalso be melted and attached, or glued, to the upper surface of thebottom member 80, at such a strength that it is peeled when you turn themain-body member 20 manually. Furthermore, the flat-plate portion 94 ofthe inner-lid member 82 may also be circular which has two openingsleading to the liquid-medicine outlets 28. Alternatively, thecylindrical member 22 and the bottom member 80 may also be united, sothat only the main-body member 20 and the inner-lid member 82 can beturned. Alternatively, three or more liquid-medicine outlets 28 may alsobe formed. In that case, the inner-lid member 82 is produced which canopen and close all those liquid-medicine outlets 28.

[0090] The liquid-medicine injection port device 10 shown in FIG. 22 isan example in which an open-and-close valve 100 which blocks the liquidpassageway 36 is used as the closure. FIG. 23 shows an operation member102 used in this liquid-medicine injection port device 10. Theopen-and-close valve 100 is shaped like a disk so that its cross sectionhas the same configuration as that of the liquid passageway 36. In thesame way as a butterfly valve, it is turned by an operation of theoperation member 102, which penetrates the side part of the cylindricalmember 22 and is connected to the open-and-close valve 100. At the endof the operation member 102 is formed a flat lever part 104. Thisenables to confirm whether the open-and-close valve 100 is opened orclosed, and thus, to open and close it unfailingly and precisely.Furthermore, in the liquid-medicine injection port device 10 accordingto this example, such a spherical open-and-close valve 101 may be usedas shown in FIG. 24. In the open-and-close valve 101, a liquid-passagehole 106 is formed which penetrates its spherical center. If it isturned by an angle of 90 degrees, the liquid passageway 36 can be openedor closed.

[0091] The liquid-medicine injection port device 10 shown in FIG. 25 isanother example in which an open-and-close valve which blocks the liquidpassageway 36 is used as the closure. FIG. 26 shows an operation member103 used in this liquid-medicine injection port device 10. In thisexample, the open-and-close valve is used which is opened by sliding ofthe operation member 103 crossing the liquid passageway 36. In thestrip-shaped operation member 103, a circular liquid-passage hole 108 isformed substantially at an end thereof. Before it is used (orinjection-mixing is conducted), the liquid passageway 36 is blocked witha flat-plate portion 116 which is closer to the end of the operationmember 103 than the liquid-passage hole 108. When it is used, theoperation member 103 is pushed in, so that the liquid-passage hole 108can be brought to the liquid passageway 36 to open the liquidpassageway.

[0092] In the liquid-medicine injection port device 10 shown in FIG. 27,a means is used by which a partition wall 110 which blocks theliquid-medicine outlet 28 is broken by an operation of an operationmember 112 which penetrates the side part of the cylindrical member 22,and thus, the liquid passageway 36 is opened. Specifically, the thinpartition wall 110 closes a part which is the side part of the liquidpassageway 36 and where the liquid-medicine outlet 28 is to be formed.Then, this partition wall 110 is broken through with the tip of theoperation member 112. The tip of the operation member 112 is sharplypointed and faces the partition wall 110. If its rear end protrudingfrom the cylindrical member 22 is pushed in, then the partition wall 110can be broken easily. Herein, the rear end of the operation member 112and its periphery are covered with a protective film 114, therebypreventing germs or the like from getting mixed inside.

[0093] Next, the liquid-medicine container 12 according to the presentinvention will be described in detail. In one of its embodiments isprovided with some of the above described liquid-medicine injection portdevices 10. Where or how the liquid-medicine injection port device 10 isattached is not limited especially. For example, it can be attached tothe end or center of the liquid-medicine container 12. Theliquid-medicine injection port device 10 may be attached to the mainbody of the liquid-medicine container 12, preferably, bymelting-attachment, gluing or the like.

[0094]FIG. 28 shows another embodiment of the liquid-medicine container12 according to the present invention. Specifically, the liquid-medicinecontainer 12, which includes the liquid-medicine injection port device10 and the liquid-medicine discharge port device 60 which thegerm-removal filter 16 (omitted in the figure) is attached to, isprovided with two front and back sheets, and is shaped like a bag, inwhich: an injection chamber 63 provided with the liquid-medicineinjection port device 10 and a storage chamber 65 storing a liquidmedicine in advance are divided by a weak seal portion 61 which isformed by melting and attaching, or gluing, the two front and backsheets to each other at such a strength that they can be easily peeled.The weak seal portion 61 prevents the liquid medicine stored in thestorage chamber 65 from going into the liquid-medicine injection portdevice 10. This keeps the germ-removal filter 16 from deteriorating,clogging up or the like, thereby maintaining the capability of thegerm-removal filter 16 normally. When the liquid-medicine container 12is used, the weak seal portion 61 is peeled so that the injectionchamber 63 leads to the storage chamber 65. This allows injection-mixingto be easily conducted.

[0095] The means of peeling the weak seal portion 61 is not limitedespecially, but preferably, it should be peeled automatically by aliquid-medicine injection pressure. Therefore, in the embodimentespecially useful according to the present invention, the weak sealportion 61 is melted and attached, or glued, at such a strength that itis peeled by receiving a liquid-medicine injection pressure. In theliquid-medicine container 12 shown in FIG. 29, the liquid-medicineinjection port device 10 is in the corner of the liquid-medicinecontainer 12. This makes it possible to shorten the weak seal portion 61and make the injection chamber 63 small. Thereby, a liquid-medicineinjection pressure is strongly applied on the weak seal portion 61, sothat it is more certainly peeled.

[0096] Some projections are also effective in peeling the weak sealportion 61. For example, a projection for picking up and pulling may beformed in either or both of the front and back surfaces of the weak sealportion 61. In the weak seal portion 61 shown in FIG. 30, projections 67are formed for each of the front and back sheets. These projections 67are formed by slackening a front sheet 69 and a back sheet 71, andoppositely folding each of them in two. If the two projections 67 arepicked up and pulled, then the weak seal portion 61 is easily peeled andseparated into the front sheet 69 and the back sheet 71. This allows theinjection chamber 63 to lead to the storage chamber 65.

[0097] In the weak seal portion 61 shown in FIG. 31, the projection 67is provided only for the front surface. The projection 67 is a memberwhich is separated from the front sheet 69 or the back sheet 71. It isfixed on the front sheet 69, by melting-attachment, gluing or the like.The shape or material quality of the projection 67 is not limitedespecially. However, a plastic sheet is preferably used, because it iseasily fixed on the front sheet 69, and is also foldable, which helps itbe conveniently housed.

[0098] Hereinbefore, the liquid-medicine injection port device and theliquid-medicine container which this is attached to according to thepresent invention have been described in detail. However, the presentinvention is not limited to the above described citations andillustrations. The shape or configuration of the liquid-medicineinjection port device, the material quality of the inlet member, theoutlet member, the bottom member, the cap or the like, the type orconfiguration of the germ-removal filter, the method of attaching theliquid-medicine injection port device to the liquid-medicine container,the type or configuration of the liquid-medicine container, the type orquantity of a liquid medicine, the method of sterilization, or the like,can be implemented from aspects including various improvements,modifications and variations, based on the knowledge of those skilled inthe art, within the scope which does not depart from the spirit of thepresent invention.

[0099] For example, the shape of the liquid-medicine container is notlimited to a rectangle, e.g., it may also be an ellipse or the like. Inaddition, the position in which the liquid-medicine injection portdevice is attached is not limited to the edge of the liquid-medicinecontainer, e.g., it may also be attached to the side thereof. Besides,the weak seal portion may also be peeled by applying pressure on it bycompulsion via the storage chamber. Furthermore, as a similar structureto the liquid-medicine injection port device 10 shown in FIG. 16, theclosure film 30 may also be peeled, not by turning the main-body member20, but by pulling up the main-body member 20.

[0100] Industrial Applicability

[0101] In the liquid-medicine injection port device according to thepresent invention, a germ-removal filter is provided, thereby makinginjection-mixing safe. This is because even if germs or the like getmixed into a liquid medicine to be injected for the injection-mixing,they are removed with the germ-removal filter, and then, the liquidmedicine goes into the liquid-medicine container. Furthermore, a closureis provided which blocks the liquid passageway downstream from thegerm-removal filter. This prevents a liquid medicine stored in theliquid-medicine container from going into the liquid-medicine injectionport device before its use. Thereby, the germ-removal filter is keptfrom deteriorating, clogging up or the like, and thus, the capability ofthe germ-removal filter 16 is normally maintained. Furthermore, theclosure is easily opened, allowing it to be used (or injection-mixing tobe conducted) conveniently by a simple operation.

[0102] Furthermore, the closure is opened by a liquid-medicine injectionpressure. Hence, the liquid-medicine injection port device can beobtained which is capable of conducting injection-mixing easily, simplyby injecting a liquid medicine. In other words, there is no need toconduct any other operation.

[0103] Furthermore, the closure is opened by a movement of the main-bodymember. Accordingly, there is no need for any new members which open themain-body member. This allows the liquid-medicine injection port deviceto have a simple structure.

[0104] Furthermore, the closure is an open-and-close valve which isopened by an operation of the operation member which penetrates the sidewall of the liquid-medicine injection port device. Hence, theliquid-medicine injection port device can be obtained which is capableof opening the closure surely.

[0105] Furthermore, in the liquid-medicine container which is providedwith the liquid-medicine injection port device according to the presentinvention, injection-mixing can be conducted by an easy operation, and asafe liquid medicine which does not include any germs or the like can beobtained. This makes it possible to give it to a patient at ease,without worrying about any side effects such as septicemia and endotoxinshock.

1. A liquid-medicine injection port device, comprising: aliquid-medicine inlet which is formed at an upper end thereof; aliquid-medicine outlet which is formed at a lower end thereof, theliquid-medicine outlet being connected to a liquid-medicine container; aliquid passageway which connects the liquid-medicine inlet and theliquid-medicine outlet; a germ-removal filter which is provided in theliquid passageway; and a closure which closes the liquid passagewayunderneath the germ-removal filter and opens the liquid passagewayeasily.
 2. The liquid-medicine injection port device according to claim1, wherein the closure is opened by the injection pressure of a liquidmedicine which is injected from the liquid-medicine inlet.
 3. Theliquid-medicine injection port device according to claim 2, wherein theclosure is a film which blocks the liquid passageway; and the film has aweak part which is broken by a liquid-medicine injection pressure. 4.The liquid-medicine injection port device according to claim 2, whereinthe closure is a film which blocks the liquid-medicine outlet; the filmis melted and attached, or is glued, to the periphery of theliquid-medicine outlet to cover the liquid-medicine outlet; and thestrength of the melting-attachment or gluing is such a degree that thefilm is peeled by a liquid-medicine injection pressure.
 5. Theliquid-medicine injection port device according to claim 2, wherein theclosure is a cylindrical film which blocks the liquid-medicine outlet;one end thereof is fixed with kept open on the periphery of theliquid-medicine outlet to cover the liquid-medicine outlet; and theinterior surfaces of the other end thereof are melted and attached, orare glued, to each other to close the other end, at such a strength thatit is broken by a liquid-medicine injection pressure.
 6. Theliquid-medicine injection port device according to claim 2, wherein theclosure is an elastic member which blocks the liquid-medicine outlet;and the elastic member is deformed by receiving a liquid-medicineinjection pressure to open the liquid-medicine outlet.
 7. Theliquid-medicine injection port device according to claim 2, wherein theclosure is a closure member which is inserted into the liquid-medicineoutlet; and the closure member clings to the inside of theliquid-medicine outlet, at such a strength that it comes off theliquid-medicine outlet by a liquid-medicine injection pressure.
 8. Theliquid-medicine injection port device according to claim 7, wherein ameans is provided which receives the closure member that comes off theliquid-medicine outlet when a liquid medicine is injected.
 9. Theliquid-medicine injection port device according to claim 2, wherein theliquid-medicine inlet is sealed up with a rubber elastic body which ispierced with an injection needle to form a liquid-medicine storage spacebetween the liquid-medicine inlet and the germ-removal filter; acompressor is provided which compresses the inner volume of theliquid-medicine storage space; and the liquid-medicine injectionpressure of a liquid medicine which is once injected into theliquid-medicine storage space is heightened by the compressor tocompressively send the liquid medicine to the side of the germ-removalfilter.
 10. The liquid-medicine injection port device according to claim1, wherein the closure is opened by a movement of a main-body memberwhich is provided with the liquid-medicine inlet and the germ-removalfilter.
 11. The liquid-medicine injection port device according to claim10, wherein an up-and-down movement of the main-body member allows theclosure member to be moved or broken to open the closure.
 12. Theliquid-medicine injection port device according to claim 10, wherein themain-body member is slid up and down; the liquid-medicine outlet whichis formed in the side of a hanging portion of the main-body member isblocked with a slide surface when the main-body member is in an upperposition; and it is away from the slide surface and is opened when it isslid downward.
 13. The liquid-medicine injection port device accordingto claim 10, wherein a turning operation of the main-body member allowsthe closure member to be moved or broken to open the closure.
 14. Theliquid-medicine injection port device according to claim 10, wherein themain-body member is turned; the liquid-medicine outlet is formed in theside of a hanging portion of the main-body member; and an openingportion which leads to the outside is provided at a part of aturning-and-rubbing surface with which the liquid-medicine outlet is incontact.
 15. The liquid-medicine injection port device according toclaim 10, wherein underneath the main-body member, an inner-lid memberis provided which engages with the main-body member so as to turntogether with the main-body member; the inner-lid member is housed inthe liquid passageway which is relatively spacious; at least twoliquid-medicine outlets are formed which are in contact with the lowersurface of the inner-lid member and that are away from theturning-center axis of the main-body member; and the inner-lid memberhas blind parts which cover the liquid-medicine outlets from the insideand has such a shape that the liquid-medicine outlets are opened byturning of the inner-lid member.
 16. The liquid-medicine injection portdevice according to claim 1, wherein the closure is an open-and-closevalve which blocks the liquid passageway; and the open-and-close valveis opened by an operation of an operation member, which penetrates theside wall of the liquid-medicine injection port device and is connectedto the open-and-close valve.
 17. The liquid-medicine injection portdevice according to claim 16, wherein the open-and-close valve is openedby turning of the operation member.
 18. The liquid-medicine injectionport device according to claim 16, wherein the open-and-close valve isopened by sliding of the operation member which crosses the liquidpassageway.
 19. The liquid-medicine injection port device according toclaim 1, wherein the closure is a partition wall which blocks theliquid-medicine outlet; and the partition wall is broken and opened byan operation of an operation member which penetrates the side wall ofthe liquid-medicine injection port device.
 20. Aliquid-medicine-injection-port device-attached liquid-medicinecontainer, comprising the liquid-medicine injection port deviceaccording to claim
 1. 21. A liquid-medicine-injection-portdevice-attached liquid-medicine container, which is provided with aliquid-medicine injection port device and a liquid-medicine dischargeport device which a germ-removal filter is attached to, includes twofront and back sheets, and is shaped like a bag, characterized by havinga two-chamber structure in which an injection chamber provided with theliquid-medicine injection port device and a storage chamber storing aliquid medicine in advance are divided by a weak seal portion which isformed by melting and attaching, or gluing, the two front and backsheets to each other at such a strength that they are easily peeled. 22.(original) The liquid-medicine-injection-port device-attachedliquid-medicine container according to claim 21, wherein the weak sealportion is peeled by receiving the injection pressure of a liquidmedicine which is injected from the liquid-medicine injection portdevice to allow the injection chamber to lead to the storage chamber.23. The liquid-medicine-injection-port device-attached liquid-medicinecontainer according to claim 21, wherein a projection is formed ineither or both of the front and back surfaces of the weak seal portion;and the projection is picked up and pulled so that the weak seal portionis peeled and separated into the two front and back sheets.